Abstract
Human lung cultured vascular endothelial cells model was established in vitro. Two kinds of skin extracts (human burned skin extracts, HBSE, and human natural skin extracts, HNSE) were added to cultured endothelial cells. The results showed that HBSE exerted toxic effect on endothelial cells in vitro. There were significantly higher contents of ET-1, NO, TNF-alpha, and abnormal structural changes in EC in the HBSE group.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Burns* / pathology
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Cells, Cultured
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Endothelin-1 / metabolism*
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Endothelium, Vascular / cytology
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Endothelium, Vascular / metabolism*
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Humans
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Lung / blood supply
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Nitric Oxide / metabolism*
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Skin / chemistry
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Tissue Extracts / pharmacology
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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Endothelin-1
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Tissue Extracts
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Tumor Necrosis Factor-alpha
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Nitric Oxide