Analysis of vacA, cagA, and IS605 genotypes and those determined by PCR amplification of DNA between repetitive sequences of Helicobacter pylori strains isolated from patients with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma

J Clin Microbiol. 1999 Jul;37(7):2348-9. doi: 10.1128/JCM.37.7.2348-2349.1999.

Abstract

The vacA s and m genotypes and the presence of cagA and IS605 were determined in Helicobacter pylori strains from patients with mono- and multiple infections. Surprisingly, these genetic markers were not associated with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma. The presence of cagA correlated with the presence of the vacA s1 allele (P < 0.05), whereas the presence of IS605 was associated with the presence of the s2 allele (P < 0.05).

MeSH terms

  • Antigens, Bacterial*
  • Bacterial Proteins / genetics*
  • DNA Transposable Elements*
  • DNA, Bacterial / genetics*
  • Dyspepsia / complications
  • Dyspepsia / microbiology*
  • Genotype
  • Helicobacter Infections / complications
  • Helicobacter Infections / microbiology*
  • Helicobacter pylori / classification
  • Helicobacter pylori / genetics*
  • Helicobacter pylori / isolation & purification
  • Humans
  • Lymphoma, B-Cell, Marginal Zone / complications
  • Lymphoma, B-Cell, Marginal Zone / microbiology*
  • Polymerase Chain Reaction / methods
  • Repetitive Sequences, Nucleic Acid

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • DNA Transposable Elements
  • DNA, Bacterial
  • VacA protein, Helicobacter pylori
  • cagA protein, Helicobacter pylori