Abstract
Thrombembolic events as paraneoplastic complications in malignant disease account for severe morbidity and mortality in these patients. In some cases disturbance in hemostasis is the first manifestation of a neoplastic process. We report the cases of two patients with cerebral and extracerebral vessel occlusions, in whom epithelial tumors of low malignant potential (borderline-tumors) of ovary and peritoneum were diagnosed later on. In one case the removal of the tumor stopped the coagulation problems. The second patient died a few days after the first symptoms with devastating multiple vessel occlusion. In stroke of unknown aetiology a paraneoplastic process should be kept in mind. The diagnosis is more probable with recurrent thrombembolism in different body regions and when warfarin therapy was ineffective. Thoughtful coagulation studies and a tumor search program is recommended in these cases.
Publication types
-
Case Reports
-
English Abstract
-
Review
MeSH terms
-
Adult
-
Brain Ischemia / diagnosis*
-
Brain Ischemia / pathology
-
Brain Ischemia / surgery
-
Cystadenocarcinoma, Papillary / diagnosis*
-
Cystadenocarcinoma, Papillary / pathology
-
Cystadenocarcinoma, Papillary / surgery
-
Diagnostic Imaging
-
Fallopian Tube Neoplasms / diagnosis*
-
Fallopian Tube Neoplasms / pathology
-
Fallopian Tube Neoplasms / surgery
-
Fallopian Tubes / pathology
-
Female
-
Humans
-
Intracranial Embolism and Thrombosis / diagnosis
-
Intracranial Embolism and Thrombosis / pathology
-
Intracranial Embolism and Thrombosis / surgery
-
Middle Aged
-
Neoplastic Cells, Circulating
-
Neurologic Examination
-
Ovarian Neoplasms / diagnosis*
-
Ovarian Neoplasms / pathology
-
Ovarian Neoplasms / surgery
-
Ovary / pathology
-
Paraneoplastic Syndromes / diagnosis*
-
Paraneoplastic Syndromes / pathology
-
Paraneoplastic Syndromes / surgery
-
Precancerous Conditions / diagnosis*
-
Precancerous Conditions / pathology
-
Precancerous Conditions / surgery