[Cerebral ischemia as initial manifestation of neoplastic low-malignancy changes. 2 case reports and review of the literatures]

Nervenarzt. 1999 Apr;70(4):342-8. doi: 10.1007/s001150050446.
[Article in German]

Abstract

Thrombembolic events as paraneoplastic complications in malignant disease account for severe morbidity and mortality in these patients. In some cases disturbance in hemostasis is the first manifestation of a neoplastic process. We report the cases of two patients with cerebral and extracerebral vessel occlusions, in whom epithelial tumors of low malignant potential (borderline-tumors) of ovary and peritoneum were diagnosed later on. In one case the removal of the tumor stopped the coagulation problems. The second patient died a few days after the first symptoms with devastating multiple vessel occlusion. In stroke of unknown aetiology a paraneoplastic process should be kept in mind. The diagnosis is more probable with recurrent thrombembolism in different body regions and when warfarin therapy was ineffective. Thoughtful coagulation studies and a tumor search program is recommended in these cases.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Adult
  • Brain Ischemia / diagnosis*
  • Brain Ischemia / pathology
  • Brain Ischemia / surgery
  • Cystadenocarcinoma, Papillary / diagnosis*
  • Cystadenocarcinoma, Papillary / pathology
  • Cystadenocarcinoma, Papillary / surgery
  • Diagnostic Imaging
  • Fallopian Tube Neoplasms / diagnosis*
  • Fallopian Tube Neoplasms / pathology
  • Fallopian Tube Neoplasms / surgery
  • Fallopian Tubes / pathology
  • Female
  • Humans
  • Intracranial Embolism and Thrombosis / diagnosis
  • Intracranial Embolism and Thrombosis / pathology
  • Intracranial Embolism and Thrombosis / surgery
  • Middle Aged
  • Neoplastic Cells, Circulating
  • Neurologic Examination
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Ovary / pathology
  • Paraneoplastic Syndromes / diagnosis*
  • Paraneoplastic Syndromes / pathology
  • Paraneoplastic Syndromes / surgery
  • Precancerous Conditions / diagnosis*
  • Precancerous Conditions / pathology
  • Precancerous Conditions / surgery