Inhibition of human telomerase by PNA-cationic peptide conjugates

Bioorg Med Chem Lett. 1999 May 3;9(9):1273-8. doi: 10.1016/s0960-894x(99)00170-5.

Abstract

The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cations / chemistry*
  • Dose-Response Relationship, Drug
  • Humans
  • Inhibitory Concentration 50
  • Models, Genetic
  • Peptide Nucleic Acids / chemistry*
  • Polymerase Chain Reaction
  • Telomerase / antagonists & inhibitors*
  • Temperature

Substances

  • Cations
  • Peptide Nucleic Acids
  • Telomerase