[Effect of allitridi on expression of proliferating cell nuclear antigen of cultured rabbit aortic smooth muscle cell]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Oct;17(10):614-5.
[Article in Chinese]

Abstract

Objective: To observe the effect of allitridi on the expression of proliferating cell nuclear antigen (PCNA) of cultured rabbit aortic smooth muscle cell (SMC).

Methods: The expression of PCNA was examined with immunohistochemical technique (LSAB method) and the contents of superoxide dismutase (SOD), lipid peroxide (LPO), prostacyclin (PGI2) and cyclic adenosine monophosphate (cAMP) in medium were simultaneously determined.

Results: Allitridi has the effects of increasing SOD activity, decreasing LPO, elevating PGI2 and cAMP, reducing the expression of PCNA (all P < 0.05-0.01).

Conclusion: Allitridi could inhibit SMC proliferation.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allyl Compounds / pharmacology*
  • Animals
  • Antioxidants / pharmacology*
  • Aorta / metabolism
  • Cells, Cultured
  • Cyclic AMP / metabolism
  • Epoprostenol / metabolism
  • Female
  • Lipid Peroxides / metabolism
  • Male
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / metabolism*
  • Proliferating Cell Nuclear Antigen / biosynthesis*
  • Rabbits
  • Sulfides / pharmacology*
  • Superoxide Dismutase / metabolism

Substances

  • Allyl Compounds
  • Antioxidants
  • Lipid Peroxides
  • Proliferating Cell Nuclear Antigen
  • Sulfides
  • diallyl trisulfide
  • Epoprostenol
  • Cyclic AMP
  • Superoxide Dismutase