Abstract
A wave of biochemical and genetic progress has identified proteins that influence transcription by modifying chromatin. Many such factors are broadly conserved and, strikingly, occur in human diseases as partners in chromosomal translocations. Understanding the function of these factors will be key to defining mechanisms of transcriptional regulation and understanding cancers linked to aberrant chromatin modification.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acetyltransferases / genetics
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Animals
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Artificial Gene Fusion
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Chromatin / metabolism*
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DNA-Binding Proteins / genetics
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Histone Acetyltransferases
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Histone-Lysine N-Methyltransferase
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Humans
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Mutation
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Myeloid-Lymphoid Leukemia Protein
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Neoplasms / genetics
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Neoplasms / metabolism*
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Nuclear Proteins / metabolism
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Proto-Oncogenes*
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Trans-Activators / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcription, Genetic
Substances
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Chromatin
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DNA-Binding Proteins
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KMT2A protein, human
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Nuclear Proteins
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Trans-Activators
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Transcription Factors
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Myeloid-Lymphoid Leukemia Protein
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Histone-Lysine N-Methyltransferase
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Acetyltransferases
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Histone Acetyltransferases
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KAT6A protein, human