4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

A J Cocuzza; F W Hobbs; C R Arnold; D R Chidester; J A Yarem; S Culp; L Fitzgerald; P J Gilligan

doi:10.1016/s0960-894x(99)00132-8

4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

Bioorg Med Chem Lett. 1999 Apr 5;9(7):1057-62. doi: 10.1016/s0960-894x(99)00132-8.

Authors

A J Cocuzza¹, F W Hobbs, C R Arnold, D R Chidester, J A Yarem, S Culp, L Fitzgerald, P J Gilligan

Affiliation

¹ DuPont Pharmaceuticals Company, Chemical and Physical Sciences Department, Experimental Station, Wilmington, DE 19880-0500, USA.

PMID: 10230640
DOI: 10.1016/s0960-894x(99)00132-8

Abstract

A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.

MeSH terms

Cell Line
Humans
Protein Binding
Pyrimidines / chemistry
Pyrimidines / metabolism
Pyrimidines / pharmacology*
Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*
Receptors, Corticotropin-Releasing Hormone / metabolism
Recombinant Proteins / antagonists & inhibitors
Recombinant Proteins / metabolism
Structure-Activity Relationship

Substances

Pyrimidines
Receptors, Corticotropin-Releasing Hormone
Recombinant Proteins