Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkappaB alpha/NF-kappaB pathway in limb-girdle muscular dystrophy type 2A

Nat Med. 1999 May;5(5):503-11. doi: 10.1038/8385.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Apoptosis*
  • Biological Transport
  • Calpain / deficiency*
  • Calpain / metabolism
  • Cell Compartmentation
  • Cell Nucleus / pathology*
  • Child
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Female
  • Fetus
  • Fluorescent Antibody Technique
  • Humans
  • I-kappa B Proteins*
  • Male
  • Microscopy, Confocal
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / pathology
  • Muscular Dystrophies / classification
  • Muscular Dystrophies / enzymology
  • Muscular Dystrophies / metabolism*
  • Muscular Dystrophies / pathology
  • NF-KappaB Inhibitor alpha
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism*
  • Recombinant Proteins / metabolism

Substances

  • DNA-Binding Proteins
  • I-kappa B Proteins
  • NF-kappa B
  • NFKBIA protein, human
  • Recombinant Proteins
  • NF-KappaB Inhibitor alpha
  • Calpain