Tumors of the minor papilla of the duodenum are rare. We successfully and safely treated a 16 mm sessile adenoma of the minor papilla using endoscopic resection. Endoscopic retrograde cholangiopancreatography (ERCP) yielded a normal cholangiopancreatogram with blind termination of the duct of Santorini in the minor papilla. We recommend endoscopic resection and histological examination of the entire lesion for adenomas of the minor papilla in patients without pancreas divisum.