Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong

P L Ho; T L Que; D N Tsang; T K Ng; K H Chow; W H Seto

doi:10.1128/AAC.43.5.1310

Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong

Antimicrob Agents Chemother. 1999 May;43(5):1310-3. doi: 10.1128/AAC.43.5.1310.

Authors

P L Ho¹, T L Que, D N Tsang, T K Ng, K H Chow, W H Seto

Affiliation

¹ Department of Microbiology, Division of Infectious Diseases, University of Hong Kong, Hong Kong. plho@hkucc.hku.hk

Abstract

The MICs of 17 antimicrobial agents for 181 Streptococcus pneumoniae strains were determined by the E-test. Overall, 69.1% were penicillin resistant (MIC > 0.06 microgram/ml). Resistance to ciprofloxacin (MIC > 2 microgram/ml), levofloxacin (MIC > 2 microgram/ml), or trovafloxacin (MIC > 1 microgram/ml) was found in 12.1, 5.5, or 2.2% of the strains, respectively. These high rates of resistance raise concerns for the future.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Anti-Infective Agents / pharmacology*
Anti-Infective Agents / therapeutic use
Child
Drug Resistance, Multiple*
Fluoroquinolones
Hong Kong
Humans
Pneumococcal Infections / drug therapy
Pneumococcal Infections / microbiology*
Streptococcus pneumoniae / drug effects*
Streptococcus pneumoniae / isolation & purification*

Substances

Anti-Infective Agents
Fluoroquinolones