Neural correlates of recognition memory with and without recollection in patients with Alzheimer's disease and healthy controls

Neurosci Lett. 1999 Mar 19;263(1):45-8. doi: 10.1016/s0304-3940(99)00106-8.

Abstract

To dissociate recognition memory with and without recollection, event-related potentials (ERPs) of patients with Alzheimer's disease (AD) and matched controls were recorded in a test of verbal recognition memory accompanied by a source judgement. AD patients who had smaller hippocampi showed a disability to recollect the study context (source). Their ERPs elicited by correctly recognized old words compared to new items were more positive only between 300 and 500 ms with a maximum over the frontal scalp. Controls exhibited a sustained old/new effect over left temporoparietal and frontal sites. The present findings suggest that preserved recognition memory in patients with mild AD is independent of hippocampally mediated processes recollecting episodic memories.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Alzheimer Disease / pathology
  • Alzheimer Disease / physiopathology*
  • Alzheimer Disease / psychology*
  • Cerebral Cortex / physiology
  • Cerebral Cortex / physiopathology*
  • Color Perception
  • Electroencephalography
  • Evoked Potentials / physiology*
  • Evoked Potentials, Visual / physiology
  • Female
  • Frontal Lobe / physiology
  • Frontal Lobe / physiopathology
  • Hippocampus / pathology
  • Hippocampus / physiology
  • Hippocampus / physiopathology*
  • Humans
  • Language
  • Learning
  • Magnetic Resonance Imaging
  • Male
  • Memory / physiology*
  • Middle Aged
  • Parietal Lobe / physiology
  • Parietal Lobe / physiopathology
  • Psychological Tests
  • Reference Values
  • Temporal Lobe / physiology
  • Temporal Lobe / physiopathology