Somatosensory stimulus entrains spindle oscillations in the thalamic VPL nucleus in barbiturate anesthetized rats

Neurosci Lett. 1999 Mar 12;262(3):191-4. doi: 10.1016/s0304-3940(99)00081-6.

Abstract

This study reports the effect of external stimuli on spindle oscillations in the somatosensory thalamus of barbiturate anesthetized rats. Multi-unit responses to somatosensory stimuli were measured from the contralateral thalamic ventral posterior lateral (VPL) nucleus at different stimulus strengths and periods. Spindle oscillations could be entrained by the somatosensory stimuli at periods between 2 and 5 s. A resonance phenomenon described as a quiescent pre-stimulus period followed by entrained post-stimulus oscillations, was observed for somatosensory stimuli above the threshold for eliciting cortical evoked potentials and a stimulus period between 2 and 5 s. This study demonstrates an ascending pathway for localized modulation of spindle oscillations.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anesthesia
  • Animals
  • Electric Stimulation
  • Evoked Potentials, Somatosensory / drug effects
  • Evoked Potentials, Somatosensory / physiology*
  • Functional Laterality
  • Oscillometry
  • Pentobarbital / pharmacology*
  • Rats
  • Rats, Wistar
  • Reaction Time
  • Thalamic Nuclei / drug effects
  • Thalamic Nuclei / physiology*
  • Time Factors

Substances

  • Pentobarbital