Bioactive sesquiterpenes from a Taiwanese marine sponge Parahigginsia sp

C Y Chen; Y C Shen; Y J Chen; J H Sheu; C Y Duh

doi:10.1021/np980491p

Bioactive sesquiterpenes from a Taiwanese marine sponge Parahigginsia sp

J Nat Prod. 1999 Apr;62(4):573-6. doi: 10.1021/np980491p.

Authors

C Y Chen¹, Y C Shen, Y J Chen, J H Sheu, C Y Duh

Affiliation

¹ Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.

PMID: 10217711
DOI: 10.1021/np980491p

Abstract

Five new sesquiterpenes, parahigginols A-D (1-4) and parahigginic acid (5), have been isolated from a Taiwanese marine sponge Parahigginsia sp. The structural assignments of the new compounds were based on their spectral data, including 1D and 2D NMR. Biological studies revealed that compounds 2-5 exhibited cytotoxicity against murine P-388 and human KB16, A549, and HT-29 tumor cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Chromatography, High Pressure Liquid
Drug Screening Assays, Antitumor
HT29 Cells
Humans
KB Cells
Leukemia P388 / pathology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*
Spectrophotometry, Ultraviolet
Taiwan
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Sesquiterpenes