Neurofibromatosis-Noonan syndrome and acute lymphoblastic leukemia: a report of two cases

J Pediatr Hematol Oncol. 1999 Mar-Apr;21(2):158-60. doi: 10.1097/00043426-199903000-00014.

Abstract

Two boys with neurofibromatosis-Noonan syndrome in whom acute lymphoblastic leukemia (ALL) developed are described. Both patients demonstrated B-lineage leukemias with normal cytogenetics. They were treated with combination chemotherapy and remain in remission off therapy. Patients with neurofibromatosis-Noonan syndrome may be at increased risk for ALL.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child, Preschool
  • Chromosomes, Human, Pair 12 / genetics
  • Chromosomes, Human, Pair 17 / genetics
  • Genes, Neurofibromatosis 1
  • Genes, ras
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Neurofibromatoses / complications*
  • Neurofibromatoses / genetics
  • Neurofibromin 1
  • Noonan Syndrome / complications*
  • Noonan Syndrome / genetics
  • Phenotype
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*
  • Proteins / physiology
  • Remission Induction
  • Risk

Substances

  • Neurofibromin 1
  • Proteins