Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter

Neurosci Lett. 1999 Mar 5;262(2):113-6. doi: 10.1016/s0304-3940(99)00049-x.

Abstract

The serotonin transporter (5-HTT) plays a key-role in the control of serotoninergic neurotransmission and is the target of some antidepressants. Possible adaptive changes in brain 5-HT2A receptors were investigated in knock-out mice that do not express the 5-HTT. Autoradiographic labeling of these receptors by the selective antagonist [3H]MDL 100,907 and saturation experiments with cortical membranes revealed: (1) a new localization of these receptors in the external field of striatum (possibly in striosomes); (2) regional variations in adaptive changes in the density of 5-HT2A receptors in 5-HT(-/-) mutants (-30-40% in the claustrum, cerebral cortex and lateral striatum; no significant change in the striatum core) as compared to wild-type mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Binding Sites
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Cell Membrane / metabolism
  • Cerebral Cortex / cytology
  • Cerebral Cortex / metabolism*
  • Down-Regulation
  • Fluorobenzenes / metabolism
  • Heterozygote
  • Homozygote
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / physiology*
  • Membrane Transport Proteins*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mutation
  • Nerve Tissue Proteins*
  • Piperidines / metabolism
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin / metabolism*
  • Serotonin Antagonists / metabolism
  • Serotonin Plasma Membrane Transport Proteins

Substances

  • Carrier Proteins
  • Fluorobenzenes
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Piperidines
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Serotonin Plasma Membrane Transport Proteins
  • Slc6a4 protein, mouse
  • volinanserin