Application of neural networks to the follow-up of AIDS patients

Stud Health Technol Inform. 1997:43 Pt A:386-90.

Abstract

The present work aims to obtain groups of patients with similar profiles of p24 antigen concentration and of CD4+ cell counts. These two markers were chosen because their evaluation represents a significant step in the clinical follow up of HIV-1 infected subjects. The classifications were obtained by a Kohonen neural net trained in three ways: with p24 antigen profiles only, with CD4+ cell count profiles only and with both sets of profiles. The results show that the clustering fashion of the two parameters closely resembles the clustering fashion of CD4+ only rather than the one of p24Ag, both with reference to cluster formation and with reference to distance among clusters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / diagnosis*
  • Algorithms
  • Biomarkers
  • CD4 Lymphocyte Count
  • HIV Core Protein p24 / blood
  • HIV-1*
  • Humans
  • Neural Networks, Computer*
  • Prognosis

Substances

  • Biomarkers
  • HIV Core Protein p24