(+)-alpha-[11C]Dihydrotetrabenazine PET imaging in familial paroxysmal dystonic choreoathetosis

Neurology. 1999 Mar 23;52(5):1067-9. doi: 10.1212/wnl.52.5.1067.

Abstract

Clinical observations suggest a disturbance of striatal dopaminergic function in familial paroxysmal dystonic choreoathetosis (PDC). The authors used PET with [11C]dihydrotetrabenazine (DTBZ) to study striatal dopaminergic innervation in PDC. The results did not reveal abnormal DTBZ binding potential in PDC striatum. This suggests that dopaminergic abnormalities, if present, may be due to altered regulation of dopamine release or to postsynaptic mechanisms, rather than to an altered density of nigrostriatal innervation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Athetosis / diagnostic imaging*
  • Athetosis / genetics
  • Athetosis / metabolism
  • Binding Sites
  • Carbon Radioisotopes
  • Chorea / diagnostic imaging*
  • Chorea / genetics
  • Chorea / metabolism
  • Dystonia / diagnostic imaging*
  • Dystonia / genetics
  • Dystonia / metabolism
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Tetrabenazine / analogs & derivatives*
  • Tomography, Emission-Computed

Substances

  • Carbon Radioisotopes
  • dihydrotetrabenazine
  • Tetrabenazine