Down-weighting of multiple affected sib pairs leads to biased likelihood-ratio tests, under the assumption of no linkage

Am J Hum Genet. 1999 Apr;64(4):1248-52. doi: 10.1086/302315.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bias*
  • Chromosome Mapping / methods
  • Chromosome Mapping / statistics & numerical data*
  • Gene Frequency / genetics
  • Genetic Linkage / genetics*
  • Humans
  • Likelihood Functions
  • Matched-Pair Analysis*
  • Models, Genetic*
  • Nuclear Family
  • Statistical Distributions