Identification of a novel HLA-C allele, Cw*0406, in a Singapore Malay

Tissue Antigens. 1999 Feb;53(2):198-200. doi: 10.1034/j.1399-0039.1999.530212.x.

Abstract

A novel allele, C*0406, has been identified and is characterised by a single nucleotide substitution at position 196 of exon 3 when compared with its closest related allele, C*0403. The latter is found in 4/69 Chinese and 7/80 Malays while Cw*0406 was found in only one Malay individual within the study populations. The data suggest that Cw*0406 may have arisen as a relatively recent genetic event either by gene conversion or as a simple point mutation variant of Cw*0403.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Base Sequence
  • DNA, Complementary
  • HLA-C Antigens / genetics*
  • Humans
  • Molecular Sequence Data
  • Sequence Homology, Nucleic Acid
  • Singapore

Substances

  • DNA, Complementary
  • HLA-C Antigens
  • HLA-C*04:06 antigen

Associated data

  • GENBANK/AF076476