Abstract
Several different disease loci with unknown genetic background map to human Xp11. In a systematic search for novel genes, we identified a novel transcript, UXT (HGMW-approved symbol), close to the ELK1 locus in Xp11.23-p11.22. The gene is composed of seven exons and encodes a protein of 157 amino acids, which is highly conserved in mouse. We showed that UXT is ubiquitously expressed and subject to X-inactivation. No homology to any known genes was found. Database surveys indicate an abundant expression in tumor tissues.
Copyright 1999 Academic Press.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Northern
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Cell Cycle Proteins
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Contig Mapping
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Databases, Factual
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Exons
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Expressed Sequence Tags
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Humans
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Mice
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Molecular Chaperones
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Molecular Sequence Data
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Myocardium / metabolism
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Neoplasm Proteins / genetics*
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Neoplasms / genetics
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Polymerase Chain Reaction
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Tissue Distribution
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Tumor Cells, Cultured
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X Chromosome / genetics*
Substances
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Cell Cycle Proteins
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Molecular Chaperones
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Neoplasm Proteins
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UXT protein, human
Associated data
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GENBANK/AF092737
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GENBANK/AF092738