Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus

N Ota; T Nakajima; Y Shirai; M Emi

doi:10.1007/s100380050125

Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus

J Hum Genet. 1999;44(2):129-30. doi: 10.1007/s100380050125.

Authors

N Ota¹, T Nakajima, Y Shirai, M Emi

Affiliation

¹ Department of Molecular Biology, Nippon Medical School, Kawasaki, Japan.

PMID: 10083740
DOI: 10.1007/s100380050125

Abstract

The transcriptional factor nuclear factor kappa-beta (NFKB) consists of a multicomponent protein complex that plays a major role in the regulation of many viral and cellular genes. The NFKB complex has two alternative DNA binding subunits. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the NFKB subunit 1 (NFKB1) gene located at 4q23-24. High heterozygosity (0.813) makes this polymorphism a useful marker in the genetic study of disorders affecting the immune response and cell differentiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 4
DNA
Dinucleotide Repeats*
Humans
Hybrid Cells / radiation effects*
Molecular Sequence Data
NF-kappa B / genetics*
Polymorphism, Genetic*

Substances

NF-kappa B
DNA