Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens

J Neve; P A Leone; A R Carroll; R W Moni; N J Paczkowski; G Pierens; P Björquist; J Deinum; J Ehnebom; T Inghardt; G Guymer; P Grimshaw; R J Quinn

doi:10.1021/np980286+

Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens

J Nat Prod. 1999 Feb;62(2):324-6. doi: 10.1021/np980286+.

Authors

J Neve¹, P A Leone, A R Carroll, R W Moni, N J Paczkowski, G Pierens, P Björquist, J Deinum, J Ehnebom, T Inghardt, G Guymer, P Grimshaw, R J Quinn

Affiliation

¹ Queensland Pharmaceutical Research Institute, Griffith University, Brisbane, 4111, Australia.

PMID: 10075775
DOI: 10.1021/np980286+

Abstract

Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flowers of Eucalyptus albens through bioassay-guided fractionation. The structure elucidation was based on 1D and 2D NMR experiments, MS analysis, and comparison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited human plasminogen activator inhibitor type-1 at 4.7 microM without any significant effect on human tissue plasminogen activator.

MeSH terms

Benzofurans / chemistry
Benzofurans / isolation & purification*
Benzofurans / pharmacology
Eucalyptus / chemistry*
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Phloroglucinol / analogs & derivatives
Plants, Medicinal*
Plasminogen Activator Inhibitor 1 / chemistry*
Surface Plasmon Resonance

Substances

Benzofurans
Plasminogen Activator Inhibitor 1
sideroxylonal C
Phloroglucinol