Abstract
Organotypic cultures support the stratification and differentiation of keratinocytes and the human papillomavirus (HPV) life cycle. We report transcription from four novel promoters in the HPV31b upstream regulatory region during the viral life cycle in organotypic cultures. Promoter initiation was not differentiation dependent; two promoters were down-regulated upon epithelial differentiation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Cell Differentiation / genetics
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Gene Expression Regulation, Viral*
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Humans
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Keratinocytes / pathology*
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Keratinocytes / virology*
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Molecular Sequence Data
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Papillomaviridae / genetics*
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Papillomavirus Infections / genetics
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Papillomavirus Infections / pathology*
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Papillomavirus Infections / virology
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Promoter Regions, Genetic*