Cardiac material markers from tagged MR images

Med Image Anal. 1998 Dec;2(4):339-53. doi: 10.1016/s1361-8415(98)80015-7.

Abstract

Tagged magnetic resonance imaging (MRI) has shown great promise in non-invasive analysis of heart motion. To replace implanted markers as a gold standard, however, tagged MRI must be able to track a sparse set of material points, so-called material markers, with high accuracy. This paper presents a new method for generating accurate motion estimates over a sparse set of material points using standard, parallel-tagged MR images. Each tracked point is located at the intersection of three tag surfaces, each of which is estimated using a thin-plate spline. The intersections are determined by an iterative alternating projections algorithm for which a proof of convergence is provided. The resulting data sets are compatible with applications developed to exploit implanted marker data. One set of these material markers from a normal human volunteer is examined in detail using several methods to visualize the markers. Numerical results that include additional studies are also discussed. Finally, an error analysis is presented using a computer-simulated left ventricle for which material markers are tracked with an RMS error of approximately 0.2 mm for typical imaging parameters and noise levels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Computer Simulation
  • Humans
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging / methods*
  • Mathematics
  • Models, Cardiovascular
  • Myocardial Contraction
  • Ventricular Function, Left / physiology*