Abstract
The MICs of HMR 3004 and HMR 3647 at which 90% of beta-lactamase-producing Haemophilus influenzae isolates were inhibited were 4 and 2 micrograms/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase-producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / therapeutic use*
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Colony Count, Microbial
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Drug Resistance, Microbial
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Haemophilus Infections / drug therapy*
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Haemophilus Infections / microbiology
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Haemophilus influenzae* / drug effects
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Haemophilus influenzae* / enzymology
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Haemophilus influenzae* / isolation & purification
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Humans
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Ketolides*
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Macrolides*
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Mice
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Mice, Inbred C57BL
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Pneumonia, Bacterial / drug therapy*
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Pneumonia, Bacterial / microbiology
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Ketolides
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Macrolides
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RU 64004
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beta-Lactamases
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telithromycin