Studies on novel 3-isoxazolylvinyl-cephalosporins: II. Synthesis and biological activity of 7-[2-(2-aminothiazol-4-yl)-2-hydroxy-iminoacetamido] derivatives

J Antibiot (Tokyo). 1998 Dec;51(12):1122-5. doi: 10.7164/antibiotics.51.1122.

Authors

K I Choi¹, J H Cha, A N Pae, Y S Cho, Y Kim, M H Chang, S H Park, S Y Park, D Kim, D Y Jeong, Y H Kim, J Y Kong, H Y Koh

Affiliation

¹ Biochemical Research Center, Korea Institute of Science and Technology, Seoul.

PMID: 10048574
DOI: 10.7164/antibiotics.51.1122

No abstract available

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cefdinir
Cefpodoxime
Ceftizoxime / analogs & derivatives
Ceftizoxime / pharmacology
Cephalosporins / chemical synthesis*
Cephalosporins / pharmacokinetics
Cephalosporins / pharmacology*
Gram-Positive Bacteria / drug effects
Magnetic Resonance Spectroscopy
Male
Methicillin Resistance
Mice
Mice, Inbred ICR
Molecular Structure
Staphylococcus aureus / drug effects
Structure-Activity Relationship
Vancomycin / pharmacology

Substances

7-((2-aminothiazol-4-yl)-2-(N-hydroxyimino)acetamido)-3-((3-methoxyisoxazol-5-yl)ethenyl)cephalosporanic acid
7-((2-aminothiazol-4-yl)-2--(N-hydroxyimino)acetamido)-3-((3-chloroisoxazol-5-yl)ethenyl)cyclosporanic acid
Cephalosporins
Vancomycin
Ceftizoxime
Cefdinir