Lung surfactant proteins involved in innate immunity

Curr Opin Immunol. 1999 Feb;11(1):28-33. doi: 10.1016/s0952-7915(99)80006-5.

Abstract

The two lung surfactant collectins, surfactant protein (SP)-A and SP-D, are involved in host defence against infectious and allergenic agents via enhancement of killing and clearance by macrophages and neutrophils. Recent gene-knockout, protein engineering and physiological studies have emphasised the roles that SP-A and SP-D play in acute inflammatory responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Glycoproteins / immunology
  • Humans
  • Immunity, Innate*
  • Lung / chemistry
  • Lung / immunology
  • Proteolipids / immunology
  • Pulmonary Surfactant-Associated Protein A
  • Pulmonary Surfactant-Associated Protein D
  • Pulmonary Surfactant-Associated Proteins
  • Pulmonary Surfactants / immunology*

Substances

  • Glycoproteins
  • Proteolipids
  • Pulmonary Surfactant-Associated Protein A
  • Pulmonary Surfactant-Associated Protein D
  • Pulmonary Surfactant-Associated Proteins
  • Pulmonary Surfactants