Enhancement of anti-tumor immunity by injection of fibroblasts genetically engineered to produce IL-12 and to express CD70

Adv Exp Med Biol. 1998:451:353-7. doi: 10.1007/978-1-4615-5357-1_55.

Authors

V Douin-Echinard¹, P D Robbins, M T Lotze, G Favre, B Couderc

Affiliation

¹ EA-UPRES 2048, Institut Claudius Regaud, Toulouse, France.

PMID: 10026896
DOI: 10.1007/978-1-4615-5357-1_55

No abstract available

MeSH terms

3T3 Cells / transplantation
Adenocarcinoma / immunology
Adenocarcinoma / therapy*
Animals
Antigen-Presenting Cells / immunology
Antigens, CD*
CD27 Ligand
Female
Fibroblasts / transplantation*
Genetic Therapy / methods*
Immunotherapy / methods
Interleukin-12 / biosynthesis
Interleukin-12 / genetics*
Lymphocyte Culture Test, Mixed
Mammary Neoplasms, Experimental / immunology
Mammary Neoplasms, Experimental / therapy*
Membrane Proteins / biosynthesis
Membrane Proteins / genetics*
Mice
Mice, Inbred BALB C
Receptors, Immunologic / genetics
Spleen / immunology
T-Lymphocytes, Cytotoxic / immunology*
Transfection / methods
Tumor Cells, Cultured

Substances

Antigens, CD
CD27 Ligand
Cd70 protein, mouse
Membrane Proteins
Receptors, Immunologic
Interleukin-12